发明名称 |
METHOD FOR MEASURING ACTIVATED FACTOR VII LEVEL IN A SAMPLE |
摘要 |
<p>The present invention relates to a method for measuring the activated factor VII level in a sample to be tested, including the steps of: a) mixing said test sample with a plasma free of factor VII (FVII) and free of at least another factor selected from among factor VIII (FVIII), factor IX (FIX), and factor XI (FXI), the test sample + plasma having a final FVII + FVIIa concentration of 10 pM to 80 pM; b) adding initiating components from the thrombin generation reaction; c) obtaining a thrombogram when carrying out a thrombin generation test (TGT) on the mixture from step b); d) comparing at least one of the thrombogram parameters from step c) with a homologous parameter obtained from standard thrombograms established on the basis of standard samples, the activated factor VII level of which is known and varies with each standard sample; e) deducing, from step d), an activated factor VII level measurement in the test sample.</p> |
申请公布号 |
WO2010001219(A1) |
申请公布日期 |
2010.01.07 |
申请号 |
WO2009IB06099 |
申请日期 |
2009.06.29 |
申请人 |
LFB BIOTECHNOLOGIES;HILBERT, LYSIANE;MAZURIER, CLAUDINE;GRENIER, DOMINIQUE |
发明人 |
HILBERT, LYSIANE;MAZURIER, CLAUDINE;GRENIER, DOMINIQUE |
分类号 |
G01N33/86;G01N33/68 |
主分类号 |
G01N33/86 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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