COMBINATION OF MEDICAL AND PHYSICAL COOLING TREATMENT OF ISCHEMIC EFFECTS

摘要

The present invention relates to the induction of hypothermia in humans in a predictable and dose responsive fashion by use of combination of physical /mechanical hypothermia therapy and a pharmaceutical composition comprising at least one compound selected among a (1) vanilloid receptor agonists, capsaicinoids or capsaicinoid-like agonists reaching and binding to vanilloid receptors, and (2) cannabinoids or cannabimimetic agonists reaching and binding to cannabinoid receptors, and (3) adenosine receptor agonists, and (4) neurotensin receptor agonists, and (5) thyroxine derivatives, and (6) cytochrome c oxidase inhibitors and (7) oxygen tension reducers thereby inducing hypothermia, thus benefiting patients suffering from illnesses characterized by tissue anoxia.