发明名称 |
ISOINDOLONE DERIVATIVES AS MEK KINASE INHIBITORS AND METHODS OF USE |
摘要 |
The invention relates to isoindoloncs of formula, (I) with anti-cancer and/or anti- inflammatory activity and more specifically with MEK kinase inhibitory activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth, treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
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申请公布号 |
CA2727252(A1) |
申请公布日期 |
2010.01.07 |
申请号 |
CA20092727252 |
申请日期 |
2009.07.01 |
申请人 |
GENENTECH, INC. |
发明人 |
GANCIA, EMANUELA;HEALD, ROBERT ANDREW;JACKSON, PHILIP;PRICE, STEPHEN |
分类号 |
C07D209/44;A61K31/4035;A61P29/00;A61P35/00 |
主分类号 |
C07D209/44 |
代理机构 |
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地址 |
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