| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide a method for selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase by administering a pharmaceutical composition containing an HDAC inhibitor. <P>SOLUTION: The oral bioavailability of the active compound, suberoylanilide hydroxamic acid, in the pharmaceutical composition is surprisingly high, moreover, the pharmaceutical composition containing the compound unexpectedly gives rise to high, therapeutically effective blood levels of the active compound over an extended period of time. In addition, a safe, daily dosing regimen of the pharmaceutical composition is provided, and the regimen is easy to follow and results in a therapeutically effective amount of the HDAC inhibitor in vivo. <P>COPYRIGHT: (C)2010,JPO&INPIT</p> |
