发明名称 |
NOVEL DOSAGE FORMULATION |
摘要 |
<p>The invention relates to a process for preparing a pharmaceutical tablet composition which comprises an active pharmaceutical ingredient of formula I wherein the definitions are described in claim 1, or pharmaceutically acceptable acid addition salts thereof and a water soluble poloxamer in which the compound of formula I and the water soluble poloxamer are processed by hot melt extrusion, and then the hot melt extrudate is mixed with other ingredients to form a tablet, that is optionally coated with a composition comprising an immediate release film coating system and purified water. The invention also relates to such pharmaceutical compositions and hot melt extrudates.</p> |
申请公布号 |
EP1928427(B1) |
申请公布日期 |
2009.12.30 |
申请号 |
EP20060793473 |
申请日期 |
2006.09.13 |
申请人 |
F.HOFFMANN-LA ROCHE AG |
发明人 |
AHMED, HASHIM, A.;PAGE, SUSANNE;SHAH, NAVNIT, HARGOVINDAS |
分类号 |
A61K9/20;A61K31/44;A61K31/4427;A61K31/455 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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