发明名称 |
Synthesis of N-N-(3,3-dimethylbutyl)-L-alpha-aspartyl-L-phenylalanine 1-methyl ester using 3,3-dimethylbutyraldehyde precursors |
摘要 |
N-[N-(3,3-dimethylbutyl)-L- a -aspartyl]-L-phenylalanine 1-methyl ester is produced by hydrolyzing a bisulfite adduct of 3, 3-dimethylbutyraldehyde with a base in a solvent, or by regenerating 3, 3-dimethylbutyraldehyde from a hydrazone, a semicarbazone or an oxime of 3,3-dimethylbutyraldehyde by acidic hydrolysis or oxidative cleavage in a solvent, or by hydrolyzing a trimer of 3,3-dimethylbutyraldehyde with an acid in a solvent. The production methods are efficient and low cost, as compared with conventional N-[N-(3,3-dimethylbutyl)-L-±-aspartyl]-L-phenylalanine 1-methyl ester synthesis.
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申请公布号 |
EP2138506(A2) |
申请公布日期 |
2009.12.30 |
申请号 |
EP20090171874 |
申请日期 |
2004.04.30 |
申请人 |
NUTRASWEET PROPERTY HOLDINGS, INC. |
发明人 |
PRAKASH, INDRA;FURLONG, KENNETH, E.;JACKSON, HANDLEY, E. III |
分类号 |
C07K5/06;C07K5/04;C07K5/072 |
主分类号 |
C07K5/06 |
代理机构 |
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地址 |
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