METHODS TO IDENTIFY MACROMOLECULE BINDING AND AGGREGATION PRONE REGIONS IN PROTEINS AND USES THEREFOR
摘要
The present invention provides methods and computational tools based, at least in part, on computer simulations that identify macromolecule binding regions and aggregation prone regions of a protein. Substitutions may then be made in these aggregation prone regions to engineer proteins with enhanced stability and/or a reduced propensity for aggregation. Similarly, substitutions may then be made in these macromolecule binding regions to engineer proteins with altered binding affinity for the macromolecule.
申请公布号
WO2009155518(A1)
申请公布日期
2009.12.23
申请号
WO2009US47954
申请日期
2009.06.19
申请人
NOVARTIS AG;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;CHENNAMSETTY, NARESH;HELK, BERNHARD;TROUT, BERNHARDT;KAYSER, VEYSEL;VOYNOV, VLADIMIR
发明人
CHENNAMSETTY, NARESH;HELK, BERNHARD;TROUT, BERNHARDT;KAYSER, VEYSEL;VOYNOV, VLADIMIR