发明名称 |
SEQUENTIAL DRUG DELIVERY SYSTEMS |
摘要 |
The invention relates to methods and composition for improving absorption an d dissolution of active ingredients of drugs. The invention provides a method of administration of an active ingredient to a mammal through a transmucosal route that includes delivering the active ingredient to a desired site in a body of the mammal, and, sequentially, at the desired site, promoting dissolution and absorption of the active ingredient. In a preferred embodiment, the ph of the localized environment of the active ingredient is sequentially modified to promote dissolution and absorption.
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申请公布号 |
CA2451106(C) |
申请公布日期 |
2009.12.22 |
申请号 |
CA20022451106 |
申请日期 |
2002.07.10 |
申请人 |
CIMA LABS, INC. |
发明人 |
PATHER, S. INDIRAN;HONTZ, JOHN;SIEBERT, JOHN M. |
分类号 |
A61K47/46;A61K9/00;A61K9/02;A61K9/20;A61K9/22;A61K31/437;A61K31/4725;A61K31/5415;A61K45/00;A61K47/00;A61K47/02;A61K47/04;A61K47/12;A61K47/26;A61K47/36 |
主分类号 |
A61K47/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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