发明名称 |
HETEROCYCLIC DERIVATIVES AS HDAC INHIBITORS |
摘要 |
<p>This invention is related to new histone deacetylase inhibitors according to the general formula (I) wherein: the dotted line is an optional additional bond; R1 is hydrogen, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl or C1-C6 haloalkoxy; R2, R3 are, independently, hydrogen; C1-C6 alkyl; aryl; or taken together with the carbon atoms to which they are bound form a bridged bicyclic ring or a fused heterocycle; X is CH or nitrogen; Y is a bond, oxygen, (CH2)mCR4R5(CH2)n, or (CH2)oNR6(CH2)p; m, n, o, p, R4, R5 and R6 are as further defined in the specification; and pharmaceutical acceptable salts thereof.</p> |
申请公布号 |
WO2009150129(A1) |
申请公布日期 |
2009.12.17 |
申请号 |
WO2009EP57042 |
申请日期 |
2009.06.08 |
申请人 |
DAC S.R.L.;THALER, FLORIAN;VARASI, MARIO;GAGLIARDI, STEFANIA;COLOMBO, ANDREA;MINUCCI, SAVERIO;MERCURIO, CIRO |
发明人 |
THALER, FLORIAN;VARASI, MARIO;GAGLIARDI, STEFANIA;COLOMBO, ANDREA;MINUCCI, SAVERIO;MERCURIO, CIRO |
分类号 |
C07D211/58;A61K31/495;A61P35/00;C07D295/10;C07D295/18;C07D401/06;C07D401/14;C07D471/08;C07D471/10 |
主分类号 |
C07D211/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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