发明名称 |
Splice variants of human IL-23 receptor (IL-23R) mRNA and use of a delta 9 isoform in predicting inflammatory bowel diseases |
摘要 |
There is disclosed the cloning and identification of human IL-23R splice variants caused by alternative splicing of the IL-23R mRNA in human. Alternative mRNA forms occur through skipping one, multiple full exons or partial exons, within the IL-23R gene. A total of twenty-five (25) different IL-23R transcripts were identified. A novel exon deletion (exon 9) isoform in the interleukin 23 receptor is disclosed, denoted as Delta9. The present application also describes a quantitative assay to measure different IL-23R isoform. Detection of Delta9 isoform of IL-23R is predominantly present in colon and cervical tissues. A decrease in Delta9 is observed in inflamed colon tissues in Crohn's patients. There is disclosed a method of predicting Crohn's disease by measuring Delta9 isoform of IL-23R.
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申请公布号 |
US2009311694(A1) |
申请公布日期 |
2009.12.17 |
申请号 |
US20090386146 |
申请日期 |
2009.04.14 |
申请人 |
MEDICAL DIAGNOSTIC LABORATOIRIES, LLC |
发明人 |
GALLAGHER GRANT;YU RAYMOND;KAN SHIH-HSIN;MANCINI GIACOMO |
分类号 |
C12Q1/68;C07H21/02 |
主分类号 |
C12Q1/68 |
代理机构 |
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