| 发明名称 |
DUAL-ACTING ANTIHYPERTENSIVE AGENTS |
| 摘要 |
<p>The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.</p> |
| 申请公布号 |
EP2132187(A2) |
申请公布日期 |
2009.12.16 |
| 申请号 |
EP20080725019 |
申请日期 |
2008.01.31 |
| 申请人 |
THERAVANCE, INC. |
发明人 |
CHOI, SEOK-KI;FATHEREE, PAUL R.;HEGDE, SHARATH;HUDSON, RYAN;JENDZA, KEITH;MARQUESS, DANIEL;MCKINNELL, ROBERT MURRAY;SASIKUMAR, VIVEK |
| 分类号 |
C07D257/04;A61K31/18;A61K31/195;A61K31/41;A61P9/12;C07C259/06;C07C323/41;C07C323/60 |
主分类号 |
C07D257/04 |
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