TREATMENTS FOR EXCITOTOXICITY AND Aß-MEDIATED TOXICITY AND AGE-ASSOCIATED NEURONAL DYSFUNCTION

摘要

The invention relates to compounds for preventing, inhibiting or antagonising fyn from phosphorylating an amino acid residue in a molecule having an amino acid sequence shown in SEQ ID NO: 1. Typically the compound is capable of binding to fyn, to prevent fyn from migrating to a region of a nerve cell cytosol adjacent a post synaptic membrane and in one embodiment the compound holds or otherwise sequesters fyn within the nerve cell soma. The invention also relates to the treatment or prevention of conditions, diseases or syndromes that are particularly, but not exclusively, a consequence of excitotoxicity or associated with excitotoxicity.