GD COMPLEX COMPRISING DTPA-BIS-AMIDE LIGAND AND METHOD FOR PREPARING THE SAME

摘要

PURPOSE: A gadolinium complex comprising a DTPA-bis-amide ligand is provided to improve contrast enhancement compared with an existing MR contrast agent and to reduce cytotoxin when applied to an MR contrast agent for cancer dignosis. CONSTITUTION: A method for preparing a DTPA-bis-amide ligand comprises the steps of: adding DTPA-bis-anhydride to N,N-demethylformamide and then stirring them; adding 2-hydroxyethyl-trans-4-(aminomethyl)cyclohexaneethylcarboxylate hydrochloride to the mixture and then stirring them; removing solvent from the mixture under low pressure and putting methanol to obtain the mixture solution, and then performing silica gel chromatography; and obtaining the ligand L4 by drying the material obtained from the third step in a vacuum condition.