发明名称 Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same
摘要 The present invention provides a compound having a formula: where R1 is selected from the group consisting of alkyl, CH2(OC2H4)OCH3, and -(OC2H4)OCH3; n is 0-4; Olig is an oligomer having a formula: -L-O-PAGR.R2]q where L is a optional linker moiety selected from the group consisting of -CH2O-, -CH2OX-, -OX-, -C(O)-, -C(O)X, -NH-, -NHC(O)-, -XNHC(O)-, -NHC(O)X-, -C(O)NH-, -C(O)NHX-, and where X is alky1-6 or is not present, Y is N or O or is not present, and R3 is alkyl1-6; PAG is a linear or branched polyalkylene glycol moiety; R2 is an alkyl1-22 capping moiety if X is present or alkyl2-22 if X is not present; and q is a number from 1 to the maximum number of branches on PAG; and m is 1-5.
申请公布号 US7625995(B2) 申请公布日期 2009.12.01
申请号 US20080037445 申请日期 2008.02.26
申请人 BIOCON LIMITED 发明人 EKWURIBE NNOCHIRI;ODENBAUGH AMY L.
分类号 A61K38/00;A61K;C07C43/23;C07C45/67;C07C45/71;C07C47/575;C07C49/84;C07C235/48;C07C271/22;C07C271/28;C07K14/00 主分类号 A61K38/00
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