发明名称 MORPHOLINE DERIVATIVES FOR USE AS DOPAMINE AGONISTS IN THE TREATMENT OF I.A. SEXUAL DYSFUNCTION
摘要 The present invention provides for compounds of formula (I), (la) and (lb) Wherein: A is selected from C-X and N, B is selected from C-Y and N, R1 is selected from H and (C1-C6)alkyl R2 is selected from H and (C1-C6)alkyl, X i s selected from H, HO, C(O)NH2, NH2 Y is selected from H HO,, NH2, Br, Cl and F Z is selected from H, HO, F, CONH2 and CN; And pharmaceutically acceptable salts, solvates and prodrugs thereof; With the provisos that: for a compound of formula (I), (la) or (lb), when A is C-X, B is C-Y, at least one of X, Y and Z must be OH; for a compound of formula (I), when A is C-X and B is C-Y, Y is H, Z is H, R1 is H and R2 is H, then X cannot be OH; these compounds are useful as dopamine agonists for the treatment of i.a. secual dysfunction.
申请公布号 CA2508262(C) 申请公布日期 2009.12.01
申请号 CA20032508262 申请日期 2003.12.02
申请人 PFIZER INC. 发明人 WONG, STEPHEN KWOK-FUNG;HEPWORTH, DAVID;COOK, ANDREW SIMON;BAXTER, ANDREW DOUGLAS;ALLERTON, CHARLOTTE MOIRA NORFOR
分类号 C07D413/04;A61K31/5375;A61K31/5377;A61P15/00;C07D265/30 主分类号 C07D413/04
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