发明名称 Azepinoindole derivatives with affinity for the farnesoid X receptor
摘要 Disclosed are compounds of formula (I), wherein the substituents are as defined in the specification. The compounds modulate the activity of the farnesoid X receptor, and are useful in treating, preventing, or ameliorating hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, dyslipidemia, lipodystrophy, atherosclerosis, atherosclerotic disease, atherosclerotic disease events, atherosclerotic cardiovascular disease, Syndrome X, diabetes mellitus, type II diabetes, insulin insensitivity, hyperglycemia, cholestasis and obesity.
申请公布号 NZ548179(A) 申请公布日期 2009.11.27
申请号 NZ20040548179 申请日期 2004.12.01
申请人 EXELIXIS, INC. 发明人 BUSCH, BRETT;FLATT, BRENTON T;GU, XIAO-HUI;MARTIN, RICHARD;MOHAN, RAJU;WANG, TIE-LIN;WU, JASON H
分类号 A61K31/435;A61K31/55;A61P31/04;A61P31/10;C07D471/04;C07D487/04;C07D487/10;C07D491/04;C07D491/20 主分类号 A61K31/435
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