LIQUID STABLE COMPOSITION OF OXAZAPHOSPHORINE WITH MESNA

摘要

A low toxicity, stable oxazaphosphorine containing compositions with mesna for parenteral administration has been described. The process essentially requires addition of an oxazaphosphorine antineoplastic to the aqueous solution of an etherified &bgr;-cyclodextrin followed by addition of mesna as such or as an aqueous solution containing optionally, an etherified &bgr;-cyclodextrin. Preferably, the oxazaphosphorine antineoplastic is Ifosfamide and the etherified &bgr;-cyclodextrin is 2-hydroxypropyl-&bgr;-cyclodextrin.