摘要 |
<p>In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. In certain aspects, the disclosure demonstrates that antagonists of BMP9 and/or BMP10, ligands for ALK1, may also be used to inhibit angiogenesis in vivo.</p> |
申请人 |
ACCELERON PHARMA, INC.;SEEHRA, JASBIR;KNOPF, JOHN;PEARSALL, ROBERT, S.;GRINBERG, ASYA;KUMAR, RAVINDRA |
发明人 |
SEEHRA, JASBIR;KNOPF, JOHN;PEARSALL, ROBERT, S.;GRINBERG, ASYA;KUMAR, RAVINDRA |