发明名称 |
CONTROLLED RELEASE OF ACTIVES IN SKIN |
摘要 |
<p>Topical compositions are provided in which active compounds for topical delivery through the stratum corneum are complexed with nanospheres of a triblock copolymer having an A-B-A structure wherein each A end block is a water-soluble, hydrophilic and non-toxic polymer or oligomer; and the hydrophobic middle B block is a hydrophobic polymer or oligomer with the same or different repeating units having the structure according to formula:(I) wherein X is —C(=O)—R—C(=O)— or —C(=O)—; Z is between 2 and about 100, inclusive; R1 is CH=CH or (CH2)n, wherein n is from 0 to 18, inclusive; R2 is selected from hydrogen and straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms; and R is selected from a bond or straight and branched alkyl, alkoxy, alkylaryl and alkoxyaryl groups containing up to 18 carbon atoms.</p> |
申请公布号 |
EP2114377(A2) |
申请公布日期 |
2009.11.11 |
申请号 |
EP20080728780 |
申请日期 |
2008.01.31 |
申请人 |
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY |
发明人 |
KOHN, JOACHIM, B.;MICHNIAK, BOZENA;DEVORE, DAVID;SHEIHET, LARISA;CHANDRA, PRAFULLA;BATHEJA, PRIYA |
分类号 |
A61K8/90;A61K9/06;A61K9/70;A61K47/48;A61Q5/02;A61Q5/12;A61Q15/00;A61Q17/04;A61Q19/00;A61Q19/02;A61Q19/04 |
主分类号 |
A61K8/90 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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