发明名称 |
Use of CpG oligodeoxynucleotides to induce angiogenesis |
摘要 |
This disclosure provides a method of inducing production of vascular endothelial growth factor by a cell. The method includes contacting the cell with a CpG oligonucleotide, thereby inducing the production of vascular endothelial growth factor by the cell. The disclosure further provides a method inducing neovascularization in a tissue. This method includes comprising introducing a CpG oligodeoxynucleotide into an area of the tissue wherein the formation of new blood vessels is desired, thereby inducing neovascularization in the area of the tissue.
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申请公布号 |
US7615227(B2) |
申请公布日期 |
2009.11.10 |
申请号 |
US20040499597 |
申请日期 |
2004.06.17 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
KLINMAN DENNIS M.;ZHENG MEI;ROUSE BARRY T. |
分类号 |
A61K39/00;A61K31/711;C12N15/117 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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