发明名称 |
DNA COMPOSITION FOR ELICITING AN IMMUNE RESPONSE AGAINST TUMOR-ASSOCIATED MACROPHAGES |
摘要 |
The present invention provides a DNA composition comprising a DNA minigene construct that encodes for a polypeptide comprising a plurality of immunogenic fragments of a cysteine endopeptidase that is expressed in tumor-associated cells. The immunogenic fragments are joined together serially by a linker peptide between each successive fragment in the polypeptide. The polypeptide is capable of eliciting an immune response against the tumor-associated cells, is expressible in immune cells, and is incorporated in a pharmaceutically acceptable carrier.
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申请公布号 |
US2009275642(A1) |
申请公布日期 |
2009.11.05 |
申请号 |
US20070311379 |
申请日期 |
2007.10.05 |
申请人 |
REISFELD RALPH A;XIANG RONG;LUO YUNPING |
发明人 |
REISFELD RALPH A.;XIANG RONG;LUO YUNPING |
分类号 |
A61K48/00;A61P35/00;C07H21/04;C12N15/63 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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