Bio-mimetic model systems for adjusting dissemination of cosmetic and pharmaceutical formulations onto human skin

摘要

Device (I) comprises a skin substitute for investigating the behavior of cosmetic and/or pharmaceutical compositions to be applied topically, where the skin substitute is a three-dimensionally crosslinked polyacrylamide matrix in which water and at least one polypeptide are bonded in the matrix. An independent claim is included for a process for adapting (I) to a series of compositions to be investigated, comprising (a) determining parameters (C 1) and n of the spreading behavior of compositions in the course of a panel test, (b) varying the percentage mass fraction (wt/wt.) of crosslinker monomers of the sum of crosslinker monomers and acrylamide monomers (C) and the percentage fraction (wt./vol) of the sum of acrylamide and crosslinker together in aqueous solution (T) values of the polyacrylamide matrix of the polypeptide and/or its concentration and/or the pH and/or the way in which the polypeptide is introduced into the matrix to give various embodiments and determining parameters (C 1) and n of the spreading behavior of the compositions for each embodiment and (c) comparing the parameters from (a) and (b) and selecting an embodiment of (I) with the polyacrylamide matrix which exhibits the greatest correlation of the measurement data.