3-PHENYLPYRAZOLO[5,1-b]THIAZOLE COMPOUND

摘要

Disclosed is a compound represented by formula (I) or a salt thereof, which has an excellent antagonistic activity on a CRF receptor and also has sufficient levels of a pharmacological activity, safety and in vivo kinetics for use as a medicinal agent. [In the formula, R1 represents a group represented by formula -A11-A12; R2 represents a tetrahydrofurylmethyl group, a tetrahydropyranylmethyl group or a tetrahydropyranyl group; A11 represents a single bond, a methylene group or a 1,2-ethylene group; A12 represents a C1-6 alkyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkyl group having a methyl group; R3 represents a methoxy group, a cyano group, a cyclobutyloxymethyl group, a methoxymethyl group or an ethoxymethyl group; and R4 represents a methoxy group or a chlorine atom.]