发明名称 |
DESIGN AND SYNTHESIS OF DIRECTED SEQUENCE POLYMER COMPOSITIONS AND ANTIBODIES THEREOF FOR THE TREATMENT OF PROTEIN CONFORMATIONAL DISORDERS |
摘要 |
The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder. |
申请公布号 |
CA2759118(A1) |
申请公布日期 |
2009.10.22 |
申请号 |
CA20092759118 |
申请日期 |
2009.04.17 |
申请人 |
DECLION PHARMACEUTICALS, INC. |
发明人 |
BONNIN, DUSTAN;ZANELLI, ERIC;MATHERS, THOMAS |
分类号 |
A61K39/145;C07K1/04 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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