| 摘要 |
<P>PROBLEM TO BE SOLVED: To discover gene mutation taking part in synostosis, to provide a method for judging onset risk of the disease based thereon, and to provide a variant FGF having modified affinity to sulfated glycosaminoglycan, and modified interstitial diffusibility. <P>SOLUTION: The method for judging the onset risk of the synostosis includes detecting the presence or absence of the substitution of Asn143 of FGF9 polypeptide with Thr, or the mutation of a codon encoding the Asn143 in Fgf9 gene to a codon encoding the Thr. The mutant FGF polypeptide in which the Asn taking part in hydrogen bond between monomers in an FGF homodimer is substituted with the Thr is also provided. <P>COPYRIGHT: (C)2010,JPO&INPIT |
