发明名称 |
Live Attenuated Bordetella Strains as a Single Dose Vaccine Against Whooping cough |
摘要 |
A mutated Bordetella strain comprising at least a mutated ptx gene, a deleted or mutated dnt gene and a heterologous ampG gene is provided. The attenuated mutated Bordetella strain can be used in an immunogenic composition or a vaccine for the treatment or prevention of a Bordetella infection. Use of the attenuated Bordetella strain for the manufacture of a vaccine or immunogenic composition, as well as methods for protecting mammals against infection by Bordetella are also provided.
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申请公布号 |
US2009246222(A1) |
申请公布日期 |
2009.10.01 |
申请号 |
US20070224895 |
申请日期 |
2007.03.07 |
申请人 |
INSTITUTE PASTEUR DE LILLE;INSTITUTE NATIONAL DE LA SANTE DE LA RECHERCHE MEDICALE (INSERM) |
发明人 |
LOCHT CAMILLE;MIELCAREK NATHALIE;DEBRIE ANNE-SOPHIE;RAZE DOMINIQUE;BERTOUT JULIE |
分类号 |
A61K39/02;A61P31/04;C12N1/21 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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