| 摘要 |
The invention is based on the surprising finding that in mammalian lungs c-myc acts as a molecular switch, specifically inducing an expression pattern in vivo, which results in prototypical mammalian adenocarcinoma of the lung and liver metastasis. A set of factors essential for the processes of tumorigenesis and tumor progression, i.e. cell cycle and apoptosis, cell growth, extracellular signaling, angiogenesis and invasion, is identified, whose expression is significantly changed. In particular, the expression pattern found uncovers the network of molecules leading to mammalian papillary adenocarcinomas of the lung. The aim of the present invention is therefore to make available a medicament, compositions, and substances directed to novel c-myc modulated factors, and the use of said compositions and substances for labelling, identifying, and treating adenocarcinoma of the lung, in particular papillary adenocarcinoma of the lung. The invention concerns a medicament for the treatment of lung carcinoma comprising a composition that decreases the expression or activity of a c-myc modulated gene selected from the group consisting of Pcr1, Klt4, Ect2, Cdc20, Stk6, Nek6, Ect2, Birc5, Hspa9a, Cideb Pglyrp, Zfp239, Elf5, Uck2, Smarcc1, Arg1, Hk1, Gapd, Suclg2, Tpi, Gnpnat1, Pign, Gapd, Mre11a, Top2a, Ard1, Hmgb2, Xrcc5, Rrm1, Rrm2, Smarcc1, Npm3, Nol5, Lamr1, H1fx, Lmnb1, Spnr, Npm3, NoIa1, Mki67ip, Ppan, Rnac, Grwd1, Srr, Pycs, Pcbd, Mrps5, Lamr1, Mrpl12, Rpl44, Eif2b, Tomm40, Slc15a2, Slc4a7, Slc4a4, Rangnrf, Kpnb3, Ipo4, MIp, Stk39, Rbp1, Reck, Areg, Ros1, Arhu, Frat2, Traf4, Myc, Frat2, Cldn2, Gjb3, Gja1, Krt1-18, CoI15a1, Dsg2, Ect2, Lcn2, Kng, Hgfac, Adora2b, Spint1, Adam19, Hpn and/or increases the expression or activity of a c-myc modulated gene selected from the group consisting of Cdkn2d, Lats2, Hey1, Stat1, Bnip2, Capn2, Anp32a, Madh6, Foxf1a, Tbx3, Tcf21, Gata3, Sox2, Crap, Trim30, KIf7, Sox17, Sox18, Meis1, Foxf2, Satb1, Anp32a, Bmp6, Tgfb1, Dpt, AcvrI1, Eng, Zfhx1a, Igfbp5, Igfbp6, Igfbp4, Socs2, Nfkbia, Sox7, Ptpre, Ptpns1, Rassf5, Fkbp7, Sema3f, VsnI1, Reck, Capn2, Cdh5, Spock2, Thbd, Tie1, Icam2, Tek, Nes, Vwf, Xlkd1, SparcI1, Marcks, Tenc1, Pcdha6, Lama4, Lama3, Pcdha4, Vtn, Vcam1, Tna, Stab1, Cldn5, Pmp22, Ptprb, Ptprg, Slfn2, Ndr2, Ets1, Sipa1, Ndn, Meox2, Rbp1, Sema7a, Sema3c, Sema3e, Tagln, Ablim1. |
