| 摘要 |
<p>Disclosed are purine nucleoside compounds that are selective to A<SUB>3 </SUB>adenosine receptors and are useful for the treatment of cancer and inflammatory diseases. The compounds are shown by the following general formula (I), including isomers thereof: wherein X is sulfur or oxygen; R<SUB>1 </SUB>is hydrogen, alkyl, benzyl, halobenzyl, or phenylalkyl; R<SUB>2 </SUB>is hydrogen, halogen, alkoxy, alkenyl, alkynyl, alkylthio, or thio; R<SUB>3 </SUB>and R<SUB>3'</SUB> are hydrogen, hydroxyalkyl, alkoxycarbonyl, or alkylaminocabonyl, whereas R<SUB>3 </SUB>and R<SUB>3</SUB>' do not have identical substituents simultaneously; and R<SUB>4 </SUB>is hydrogen or alkyl. Also disclosed are a pharmaceutical composition comprising a compound of formula (I), an isomer, or its pharmacologically acceptable salt as an active ingredient and a method for preventing or treating various diseases, state, or condition, including asthma, inflammation, cerebral ischemia, heart diseases, and cancer.</p> |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;EWHA WOMANS UNIVERSITY |
发明人 |
JEONG, LAK SHIN;JACOBSON, KENNETH, A.;MOON, HYUNG RYONG;KIM, HEA OK |
