THREE DIMENSIONAL COORDINATES OF HYPOXIA INDUCIBLE FACTOR 1 ALPHA (HIF-1 ALPHA) PROLYL HYDROXYLASE (EGLN1) AND USES THEREOF

摘要

The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate EGLN1 prolyl hydroxylase and thereby regulate HIF-regulated disorders.