发明名称 |
A PROCESS FOR THE PREPARATION OF OPTICALLY PURE R (-) SALBUTAMOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS |
摘要 |
<p>A process for the preparation of optically pure R (−) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate and C1 to C4 branched or normal chain alcohol for dissolution of the racemic mixture and resolving agent and purification of the 4-nitro tartranilic acid salt of R (−) salbutamol. 4-nitro tartranilic acid salt of R (−) salbutamol is converted into formic acid salt of R (−) 4-benzyl salbutamol followed by basification and debenzylation to form optically pure R (−) salbutamol. Optically pure (R)-salbutamol is obtained in good yield and high purity. The optically pure R (−) salbutamol is optionally converted into pharmaceutically acceptable salts.</p> |
申请公布号 |
EP2099740(A1) |
申请公布日期 |
2009.09.16 |
申请号 |
EP20060842766 |
申请日期 |
2006.09.25 |
申请人 |
AARTI HEALTHCARE LIMITED |
发明人 |
DESAI PARIMAL, HANSMUKH;SALVI NARENDRA, JAGANNATH;PATRAVALE BHARATKUMAR, SURENDRA;SEETHARAMAN, SUBRAMANIAN;PATIL DILIP, JIBHAU;GHOGARE KHANDU, SHANKAR |
分类号 |
C07C213/10;C07B57/00;C07C215/60;C07C217/70 |
主分类号 |
C07C213/10 |
代理机构 |
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代理人 |
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地址 |
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