METHODS OF INCREASING EPIDERMAL SKIN THICKNESS BY TOPICAL ADMINISTRATION OF A 19-NOR CONTAINING VITAMIN D COMPOUND

摘要

Methods of increasing the thickness of the epidermal layer in the skin of a human comprising topically administering a therapeutically effective dose of an active pharmaceutical ingredient comprising a vitamin D analog including 2-methylene-19-nor-20(S)-1a-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(S)-2-methylene-1a,25-dihydroxyvitamin D3, 2-methylene-19-nor-(24R)-1a,25-dihydroxyvitamin D2, 2-methylene-1a,25-dihydroxy-(17E)-17(20)-dehydro-19-nor-vitamin D3, 2-methylene-(20R,25S)-19,26-dinor-1a,25-dihydroxyvitamin D3, 2-methylene-18,19-dinor-(20S)-1a,25-dihydroxyvitamin D3, 2-methylene-19-nor-1a-hydroxy-pregnacalciferol, 1a-hydroxy-2-methylene-19-nor-homopregnacalciferol, (20R)-1a-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-19-nor-la-hydroxy-trishomopregnacalciferol, 2-methylene-(20R)-23,23-difluoro-1a-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20S)-23,23-difluoro-1a-hydroxy-19-nor-bishomopregnancalciferol, 2-(3'hydroxypropyl-1',2'-idene)-19,23,24-trinor-(20S)-1a-hydroxyvitamin D3, or 13,13-dimethyl-des-C,D analog of (20S)-2-methylene-1a,25-dihydroxy-19-nor-vitamin D3, and pharmaceutical topical formulations and topical dosage forms thereof using a pharmaceutically suitable carrier vehicle.