PPAR-DELTA LIGANDS AND METHODS OF THEIR USE

摘要

The disclosure provides compounds, compositions, and methods for modulating PPARd receptor. In one embodiment, the compounds of the disclosure comprise a tri-substituted thiazole group. The substituent at the 2-position of the thiazole group provides steric bulk to the compounds. The compounds, compositions, and methods may be useful, for example, in the treatment of cancer.