| 摘要 |
A method for manufacturing an optically pure (S)-3-hydroxypyrrolidine is provided to reduce the manufacturing cost using a compound and enhance the yield. An optically active (S)-3-hydroxypyrrolidine of the chemical formula 1 is produced by reacting optically active 4-amino-(S)-hydroxybutylic acid ester salt of the chemical formula 2 under the presence of reductant. In the chemical formula 1 or 2, R is linear or branched alkyl of 1-10 carbon atoms, aryl, or aralkyl, and HX is halogeno acid, sulfuric acid, phosphoric acid or methanesulphonic acid. The reductant is borane, sodium borohydride, lithium triethyl borohydride, or lithium aluminum hydride.
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