Benzimidazole derivatives and their use as protein kinase inhibitors

摘要

Disclosed is a compound of formula (IV), or a salt, N-oxide, or solvate thereof, where A is NH(C=O), O(C=O), or C=O, and wherein the other substituents are as described in the specification. Also disclosed is a method of synthesis for the compound. Also disclosed is the use of the compound for treating a condition mediated by a cyclin dependent kinase, glycogen synthase kinase, or Aurora kinase, such as: carcinoma of the bladder, breast, colon, kidney, epidermis, liver, lung, oesophagus, gall bladder, ovary, pancreas, stomach, cervix, thyroid, prostate, or skin; a hematopoietic tumour of lymphoid lineage; a hematopoietic tumour of myeloid lineage; thyroid follicular cancer; a tumour of mesenchymal origin; a tumour of the central or peripheral nervous system; melanoma; seminoma; teratocarcinoma; osteosarcoma; xeroderma pigmentosum; keratoctanthoma; thyroid follicular cancer; Kaposi's sarcoma; a hematopoietic tumour of lymphoid lineage selected from leukemia, acute lymphocytic leukemia, B-celllymphoma, T-cell lymphoma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, hairy celf lymphoma, and Burkett's lymphoma; a hematopoietic tumour of myeloid lineage selected from acute and chronic myelogenous leukemias, myelodysplastic syndrome, and promyelocytic leukemia; cancer selected from breast cancer, ovarian cancer, colon cancer, prostate cancer, oesophageal cancer, squamous cancer, non-small cen lung carcinomas, breast cancer, bladder cancer, colorectal cancer, pancreatic cancer, ovarian cancer, non-Hodgkin's lymphoma, gliomas and non-endometrioid endometrial carcinomas.