| 摘要 |
PROBLEM TO BE SOLVED: To provide new substances having a macrophage intrafat drop accumulation-inhibiting action and originated from a microorganism. SOLUTION: Provided is the method for producing new FKI-1746-1 and FKI-1746-2 substances, characterized by culturing a microorganism belonging to genus Aspergillus and having ability to produce the FKI-1746-1 and FKI-1746-2 substances, especially Aspergillus clavatonanicus FKI-1746 (FERM AP-21482), in a culture medium, and then collecting the FKI-1746-1 and/or FKI-1746-2 substances from the culture product. The new substances have a macrophage intrafat drop accumulation-inhibiting action, and are effective for preventing and treating arteriosclerosis and diseases caused by the arteriosclerosis. COPYRIGHT: (C)2009,JPO&INPIT
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