发明名称 |
METHOD FOR PREVENTION OF COLORATION IN DONEPEZIL-CONTAINING SKIN ADHESIVE PREPARATION, AND METHOD FOR REDUCING THE PRODUCTION OF DONEPEZIL ANALOGUE IN DONEPEZIL-CONTAINING SKIN ADHESIVE PREPARATION |
摘要 |
<p>[Object] By suppressing coloring of an adhesive preparation containing donepezil, a naturally colored appearance is realized. [Solution] In a method for suppressing coloring of an adhesive preparation having a support and a pressure-sensitive adhesive layer, which comprises a pressure-sensitive adhesive and donepezil in the pressure-sensitive adhesive layer, ascorbic acid, a metal salt or an ester thereof and metal metabisulfite salt are contained in the pressure-sensitive adhesive layer. This method preferably has: a step of preparing a mixture comprising the pressure-sensitive adhesive, the donepezil, the ascorbic acid, a metal salt or an ester thereof, and the metal metabisulfite salt; and a step of film-forming the pressure-sensitive adhesive layer by applying the mixture to the surface of the support.</p> |
申请公布号 |
EP2090310(A1) |
申请公布日期 |
2009.08.19 |
申请号 |
EP20070849959 |
申请日期 |
2007.11.30 |
申请人 |
NITTO DENKO CORPORATION;EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
NISHI, SUMIYO;HANATANI, AKINORI;SEKIYA, JUNICHI;TERASHI, SACHIKO;AKEMI, HITOSHI;WASHIRO, SATOKO |
分类号 |
A61K31/445;A61K9/70;A61K47/02;A61K47/14;A61K47/20;A61K47/22;A61K47/32;A61P25/28 |
主分类号 |
A61K31/445 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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