THE CO-CULTURE METHOD OF SPHINGOMONAS SP. BACTERIAL STRAIN AND ASPERGILLUS SP. FUNGUS STRAIN, NEW ANTI-CANCER AND ANTIBIOTIC GLIONITRINS DERIVED FROM THIS CO-CULTURE METHOD, AND PHARMACEUTICAL COMPOSITION CONTAINING GLIONITRINS OR PHARMACEUTICALLY AC

摘要

The present invention relates to a co-culture method of Sphingomonas sp. bacterial strain and Aspergillus sp. fungus strain, in which the novel Sphingomonas sp. bacterial strain KMK-001 is cultured in a liquid medium and the novel Aspergillus sp. strain KMC-901 separately cultured in another liquid medium is added to the above culture solution, a novel glionitrin biosynthesized therefrom and a pharmaceutical composition comprising the said glionitrin or its pharmaceutically acceptable salt as an active ingredient. The glionitrin herein has strong cytotoxic effect on cancer cells and has antibiotic effect on 10 pathogenic bacteria including the novel Sphingomonas sp. bacterial strain KMK-001, so that it can be effectively applied in antibiotics or anti-cancer agents.