摘要 |
<p>The present invention relates to methods and assays for identifying agents capable of inhibiting the mutant huntingtin protein, inhibiting or reducing cell death, in particular cell death associated with polyglutamine-induced protein aggregation, which inhibition is useful in the prevention, amelioration and / or treatment of neurodegenerative diseases, and Huntington's disease more generally. In particular, the present invention provides methods and assays for identifying agents for use in the prevention and / or treatment of Huntingtons disease. The invention provides polypeptide and nucleic acid TARGETs and siRNA sequences based on these TARGETS.</p> |
申请人 |
BIOFOCUS DPI B.V.;FISCHER, DAVID FREDERIK;JANSSEN, RICHARD ANTONIUS JOZEF;DE PRIL, REMKO;VAN STEENHOVEN, DESIRE MARIA PETRONELLA CATHARINA;KWAK, SEUNG;HOWLAND, DAVID S.;SIGNER, ETHAN |
发明人 |
FISCHER, DAVID FREDERIK;JANSSEN, RICHARD ANTONIUS JOZEF;DE PRIL, REMKO;VAN STEENHOVEN, DESIRE MARIA PETRONELLA CATHARINA;KWAK, SEUNG;HOWLAND, DAVID S.;SIGNER, ETHAN |