发明名称 |
N-TERMINAL MODIFIED PEG-TRAIL, METHOD FOR PREPARING AND USES THEREOF |
摘要 |
Disclosed herein are an N-terminal modified PEG-TRAIL conjugate and a preparation method and use thereof. The PEG-TAIL conjugate has pharmaceutical activity identical or similar to that of native TRAIL (TNF-related apoptosis-inducing ligand) with extended in vivo half-life and enhanced stability. Compared to native TRAIL, the PEG-TAIL conjugate exhibits high solubility and solution stability, with highly improved pharmacokinetic profiles. Thus, the PEG-TAIL conjugate may be very useful for preventing and treating proliferative diseases and autoimmune diseases.
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申请公布号 |
US2009203599(A1) |
申请公布日期 |
2009.08.13 |
申请号 |
US20070304121 |
申请日期 |
2007.06.12 |
申请人 |
LEE KANG CHOON;CHAE SU YOUNG;YOUN YU SEOK;KIM WON BAE;LEE SUNG KWON |
发明人 |
LEE KANG CHOON;CHAE SU YOUNG;YOUN YU SEOK;KIM WON BAE;LEE SUNG KWON |
分类号 |
A61K38/16;C07K1/00;C07K14/00 |
主分类号 |
A61K38/16 |
代理机构 |
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