发明名称 Process for Production of Radioactive Fluorine-Labeled Organic Compound
摘要 A process is provided for producing [18F]FACBC, which can reduce the production amount of impurities. Disclosed is a process for producing a radioactive fluorine-labeled organic compound, including a deesterification step of retaining, in a reverse-phase column, a compound represented by Formula (1): wherein R1 is a linear or branched C1-C10-alkyl chain or an aromatic substituent, and R2 is a protecting group; charging the column with an alkaline solution to deesterify the compound, and subsequently discharging the alkaline solution from the column to obtain a compound represented by Formula (2): wherein X is sodium or potassium; and a deprotection step of deprotecting the amino-protecting group of the compound obtained in the deesterification step to obtain a compound represented by Formula (3):
申请公布号 US2009198085(A1) 申请公布日期 2009.08.06
申请号 US20070227240 申请日期 2007.05.07
申请人 NIHON MEDI-PHYSICS CO., LTD. 发明人 HAYASHI AKIO;KUROSAKI FUMIE;TOYAMA MASAHITO;SHINMURA TOSHIYUKI;KANEKO EMI
分类号 C07C61/04 主分类号 C07C61/04
代理机构 代理人
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