发明名称 |
Compare-MS: Method Rapid, Sensitive and Accurate Detection of DNA Methylation |
摘要 |
The present invention provides methods and kits useful for enriching, identifying and quantifying methylated DNA3 particularly hypermethylated CpG islands by digesting a sample with a methylation-sensitive restriction endonuclease and capturing methylated restriction fragments with a methyl-binding capture reagent. The methods of the invention may be used in the detection of cancer, particularly detection of prostate cancer.
|
申请公布号 |
US2009197263(A1) |
申请公布日期 |
2009.08.06 |
申请号 |
US20070159081 |
申请日期 |
2007.01.04 |
申请人 |
NELSON WILLIAM G;LIN XIAOHUI S;DEMARZO ANGELO M;NASUBRAMANIAN SRINIVASAN |
发明人 |
NELSON WILLIAM G.;LIN XIAOHUI S.;DEMARZO ANGELO M.;NASUBRAMANIAN SRINIVASAN |
分类号 |
C12Q1/68;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|