PROCESS FOR PRODUCTION OF ß-LACTAM COMPOUND

摘要

Disclosed is a process for producing a carbapenem compound represented by Formula [1], which is characterized by allowing a base and a Lewis-acidic metal salt to coexist in the reaction of a compound represented by Formula [2] with a compound represented by Formula [3]. According to the process, a side-chain mercaptothiazole can be introduced into a ß-lactam skeleton efficiently in the production of a ß-lactam compound having an excellent antibacterial activity against a Gram-positive bacterium. [3] [2] [1] wherein R1 represents a lower alkyl group or the like; R2 represents a hydrogen atom or the like; R3 represents a protective group for a carboxyl group; L represents an active ester of a hydroxy group; R4 represents a hydrogen atom or the like; and R5 represents a hydrogen atom or the like.