| 摘要 |
PROBLEM TO BE SOLVED: To provide a highly marketable prophylactic and therapeutic agent for arteriosclerosis exhibiting improved water solubility and pharmacokinetics as well as enhanced chemical synthesis efficiency by simplifying the skeleton structure of beauveriolide while retaining the spatial configuration of substituent groups induced by the natural skeleton of beauveriolide. SOLUTION: The cyclic compound has formula (1), wherein Y is CH<SB>2</SB>, CH<SB>2</SB>-CH<SB>2</SB>or CH=CH; n is 0 or 1; R<SB>1</SB>, R<SB>3</SB>and R<SB>4</SB>are each an alkyl group, an alkenyl group, an alkynyl group, an aryl group or an aralkyl group (each group optionally bearing a heteroatom therein and optionally being substituted with a substituent group), or an amino group (only for R<SB>4</SB>); and R<SB>2</SB>is an aryl or aralkyl group bearing at least one aromatic ring (each group optionally bearing a heteroatom therein and optionally being substituted with a substituent group). COPYRIGHT: (C)2009,JPO&INPIT
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