A MICROORGANISM OF CORYNEBACTERIUM GENUS HAVING ENHANCED XANTHOSINE 5'-MONOPHOSPHATE PRODUCTIVITY AND METHOD OF PRODUCING XANTHOSINE 5'-MONOPHOSPHATE USING THE SAME

摘要

A method for producing a xanthosine 5'-monophosphate by using Corynebacterium sp. microorganism is provided to enhance the activation of enzyme related to the purine biosynthesis and inactivate an enzyme which resolves nucleic acid. A method for improving the productivity of xanthosine 5'-monophosphate from Corynebacterium sp. microorganism is enhancing the activation of phosphoribosylglycinamide formyltransferase and inosinic acid cyclohydrolase. Two or more purNH genes which encode the enzymes are contained inside chromosome. The purNH gene as gene sequence of the sequence number 12. A method for producing a xanthosine 5'-monophosphate comprises: a step of culturing the Corynebacterium sp. microorganism to produce the xanthosine 5'-monophosphate; and a step of collecting the xanthosine 5'-monophosphate from a cell or medium.