COMPOSITIONS AND METHODS FOR PRODUCING VASCULAR OCCLUSION USING A SOLID-PHASE PLATELET BINDING AGENT
摘要
The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.
申请公布号
WO2009067791(A4)
申请公布日期
2009.07.16
申请号
WO2008CA02060
申请日期
2008.11.26
申请人
VIREXX MEDICAL CORP.;HIRSCHE, BRUCE;STEWART, MICHAEL, W.;PERSON, ROLAND, H.;GRIFFITH, IRWIN, J.;TIEGE, PAUL, B.
发明人
STEWART, MICHAEL, W.;PERSON, ROLAND, H.;GRIFFITH, IRWIN, J.;TIEGE, PAUL, B.;NOUJAIM, ANTOINE