发明名称 |
ANTI-CLDN6 ANTIBODY |
摘要 |
<p>Disclosed is an antibody capable of binding to Claudin-6 (CLDN6) which is expressed on the surface of a cell membrane. The antibody can recognize human CLDN6 occurring on the surface of a cell membrane in its native form, and has a cytotoxic activity (e.g., an ADCC activity and a CDC activity) against a cancer cell line which expresses human CLDN6 at a high level. A conjugate of the antibody and a toxin has an inhibitory activity on the cell proliferation of a cancer cell line which expresses human CLDN6 at a high level. The expression of human CLDN6 is not observed in a normal tissue, but is increased in a tumor tissue (e.g., pulmonary adenocarcinoma, gastric cancer, ovarian cancer). The anti-CLDN6 antibody is expected to be highly accumulated in a tumor in which human CLDN6 has been expressed at a high level, and therefore can be used as an extremely effective anti-tumor agent.</p> |
申请公布号 |
CA2711557(A1) |
申请公布日期 |
2009.07.16 |
申请号 |
CA20092711557 |
申请日期 |
2009.01.09 |
申请人 |
THE UNIVERSITY OF TOKYO;FORERUNNER PHARMA RESEARCH CO., LTD. |
发明人 |
ABURATANI, HIROYUKI;TSUTSUMI, SHUICHI;NISHIMURA, KUNIHIRO;SAKUMOTO, HIROFUMI;KAWAI, SHIGETO |
分类号 |
C07K16/28;A61K39/395;A61P35/00;C12N15/09;C12P21/08;G01N33/53;G01N33/574 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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