摘要 |
<p>The present invention relates to a bicyclic pyrimidine compound of the following formula (I) or a salt thereof.
wherein R 1 is lower alkyl, cyclic lower alkyl. etc.; R 2 is H, lower alkyl, lower alkenyl, etc.; R 3 is H, lower alkyl, lower alkenyl, etc.; X is O, S or -N(R 4 )-; R 4 is H or lower alkyl; or R 2 and R 4 may combine each other to form cyclic amino; Y is amido, keto, sulfonyl, etc.; R 5 is H or lower alkyl; Z is O or S; m and n are 1 or 2. Said compound (I) or a salt thereof have MGAT inhibitory activity, and are useful as an agent for treatment or prophylaxis of adiposity, metabolic syndromes, hyperlipidemia, hyper neutral lipemia, hyper VLDL-mia, hyper fatty acidemia, diabetes mellitus, arteriosclerosis.</p> |
申请人 |
DAINIPPON SUMITOMO PHARMA CO., LTD.;SUMITOMO CHEMICAL COMPANY, LIMITED |
发明人 |
NAKAMURA, KEIJI;NAKAGAWA, HIROYUKI;KAN, YOKO |