| 摘要 |
The present application relates to novel therapeutic strategies for cellular degenerative diseases, and more specifically neurodegenerative diseases. Said strategies are based on modulating one or more metabolic pathways identified by the inventors, which are correlated with the onset, development and progression of toxicity and apoptosis in cells, especially nerve cells, and are particularly pertinent in neurodegenerative diseases. The invention relates to a novel use of Unc51-Like Kinase modulator, and more specifically of Unc51-Like Kinase inhibitors. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of cellular degenerative diseases, and more specifically neurodegenerative disorders. |
