发明名称 |
MANUFACTURING PROCESS FOR NO-DONATING COMPOUNDS SUCH AS NO-DONATING DICLOFENAC |
摘要 |
The present invention relates to a new process for the preparation of NO-donating compounds using a sulfonated intermediate. The invention relates to new intermediates prepared therein suitable for large scale manufacturing of NO-donating compounds. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active NO-donating compounds. The invention further relates to a substantially crystalline form of NO-donating NSAIDs, especially 2-[2-(nitrooxy)ethoxy]ethyl {2-[(2,6-dichlorophenyl)amino]phenyl}acetate, the preparation thereof and to pharmaceutical formulations containing said crystalline form and to the use of said crystalline form in the preparation of a medicament.
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申请公布号 |
US2009170934(A1) |
申请公布日期 |
2009.07.02 |
申请号 |
US20080143100 |
申请日期 |
2008.06.20 |
申请人 |
NICOX SA |
发明人 |
ANDERSSON JOHAN;BELLI ALDO;CANNATA VINCENZO;HEDBERG MARTIN;PALMGREN ANDREAS;SCHULDEI SIGRID;STROM MARIKA;VILLA MARCO |
分类号 |
A61K31/24;C07C201/00;A61K31/216;A61P29/00;C07C203/00;C07C205/40;C07C229/42;C07C303/28;C07C309/66 |
主分类号 |
A61K31/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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