发明名称 |
PROCESS FOR PRODUCTION OF HETEROCYCLE-SUBSTITUTED PYRIDINE DERIVATIVE |
摘要 |
<p>Disclosed is a process for efficiently producing a heterocycle-substituted pyridine derivative. Specifically disclosed is a process for producing a compound represented by Formula (I), which comprises the step of reacting a compound represented by Formula (III) with a compound represented by Formula (II) in a solvent in the presence of a Pd catalyst and a base. In Formulae (I) to (III), R1 represents a hydrogen atom or the like; R2 represents a hydrogen atom, a C1-6 alkyl group, an amino group which may be protected by a protective group or the like; one of X and Y represents a nitrogen atom and the other represents a nitrogen atom or an oxygen atom; Q represents a leaving group; the ring A represents a 5- or 6-membered heteroaryl or benzene ring which may have one or two halogen atoms or C1-6 alkyl groups; Z represents a single bond, a methylene group, an ethylene group, an oxygen atom or the like; R represents a hydrogen atom, a C1-6 alkyl group or the like; R3 represents a hydrogen atom, a halogen atom or the like; and R4 represents a hydrogen atom or a halogen atom, provided that all of R1, R2 and R4 do not represent a hydrogen atom when Z represents a single bond or when R3 represents a hydrogen atom.</p> |
申请公布号 |
WO2009081970(A1) |
申请公布日期 |
2009.07.02 |
申请号 |
WO2008JP73545 |
申请日期 |
2008.12.25 |
申请人 |
EISAI R & D MANAGEMENT CO., LTD.;NIIJIMA, JUN;YOSHIZAWA, KAZUHIRO;KOSAKA, YUKI;ABE, SHINYA |
发明人 |
NIIJIMA, JUN;YOSHIZAWA, KAZUHIRO;KOSAKA, YUKI;ABE, SHINYA |
分类号 |
C07D413/04;A61K31/4439;A61P31/10;C07D413/14;C07F5/02 |
主分类号 |
C07D413/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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